Tissue microarray technology a novel research tool for oral squamous cell carcinoma: A review

Solomon, Monica Charlotte and Vidyasagar, MS and Fernandes, Donald J (2014) Tissue microarray technology a novel research tool for oral squamous cell carcinoma: A review. International Research Journal of Medical Sciences, 2 (7). pp. 21-29. ISSN 2320 –7353

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Abstract

Over the last few decades several new high throughput methods have been introduced in research for analysing the expression of a wide range of proteins that have an enormous value in diagnosis and treatment of human cancers. The Tissue microarray technology is one such novel research tools. Tissue microarray technology is a method of takingmultiple tissue cores from conventional histological paraffin blocks and placing them in a single paraffin block. Thus, the tissues from multiple patients can be seen on the same slide. It is a means of combining hundreds of tissue specimens onto a single slide for simultaneous histological analysis. This technique is grown to become a population level research tool. TMA hold an immense potential to validate multiple tumor types in a shorter time span. Tissue microarray represents a mechanism for highly effective use of scarce resources. This paper presents an overview of this novel technology, the benefits and challenges of this technique and traces the application of a combined approach of Immunohistochemistry and tissue microarray in research pertaining to oral squamous cell carcinomas.

Item Type: Article
Uncontrolled Keywords: Tissue microarray; oral squamous cell carcinoma; amplification; molecular markers; prognosis.
Subjects: Dentistry > MCODS Manipal > Oral Pathology and Microbiology
Depositing User: KMC Manipal
Date Deposited: 22 Jan 2015 04:44
Last Modified: 22 Jan 2015 04:44
URI: http://eprints.manipal.edu/id/eprint/141691

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