Musmade, Kranti P and Deshpande, Praful B and Musmade, Prashant B and Maliyakkal, Naseer M and Reddy, Sreenivasa M and Udupa, N (2014) Methotrexate-loaded Biodegradable Nanoparticles:Preparation, Characterization and Evaluation of its Cytotoxic Potential Against U-343 MGa Human Neuronal Glioblastoma Cells. Bulletin of Materials Science, 37 (4). pp. 945-951.

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Abstract

Nanoparticles represent one of the attractive alternatives in the effective treatment of cancer chemotherapy.In the present work, formulation and development of a novel methotrexate (MTX)-loaded biodegradable nanoparticles using poly(D,L-lactide-co-glycolide) (PLGA) was carried out. The prepared nanoparticles were evaluated for physicochemical properties such as particle size, zeta potential, release studies, etc and also evaluated for its in vitro cytotoxic potential against U-343 MGa human neuronal glioblastoma cells. Particle size of optimized formulation was < 200 nm. There was a considerable decrease in cell viability and enhancement in cytotoxic activity of MTX-loaded nanoparticles compared to MTX alone when tested against U-343 MGa human neuronal glioblastoma cells.

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