Wound healing effect of three traditional Medicated oils (kayathirumeniennai, Punguthailamand mathanthailam) on experimentally Induced burn wounds in wistar rats

Sabarianandh, JV and Uma, VK and Fernandes, Doel Loyed and Amuthan, Arul and Nayak, Veena (2014) Wound healing effect of three traditional Medicated oils (kayathirumeniennai, Punguthailamand mathanthailam) on experimentally Induced burn wounds in wistar rats. World Journal of Pharmacy and Pharmaceutical Sciences, 3 (5). pp. 1307-1313. ISSN 2278 – 4357

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Abstract

Traditional forms of medicine have been used for centuries. Kayathirumeniennai, punguthailam and mathanthailam are three important polyherbal (medicated oils) frequently used in siddha medicine for the treatment of wounds. However in view of lack of scientific validation , we planned to study the effect of these oils on burn wound healing in Wistar rats. Methodology:After obtaining IAEC clearance, the study was carried out in the central animal house, Manipal. Adult male albino rats of Wistar strains weighing 150-300g were used for the study. The animals were divided into six groups (n=6). Group 1 did not receive any drug and served as control group. Group 2 served as vehicle group and pure coconut oil was applied topically as it was the vehicle for the test drugs. Group 3 received standard treatment with silver sulphadiazine ointment. Group 4, group 5 and group 6 received three medicated oils viz. punguthailam, kaya thirumeniennai and mathanthailam respectively. All the drugs and vehicles were applied once daily, topically on the burn wound. Results: There was a significant reduction (p<0.01) in the duration (days) for epithelialization in the treated groups in comparison to control. Percentage of wound contraction was significantly increased in the groups treated with punguthailam and mathanthailam(p<0.05) in comparison to control . Conclusion: Punguthailam and mathanthailam have a potential to improve wound healing. Further studies on different models of wound healing are required to confirm the results.

Item Type: Article
Uncontrolled Keywords: Punguthailam; kaya thirumeniennai; mathanthailam; wound healing.
Subjects: Medicine > MMMC Manipal > Pharmacology
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 12 Feb 2015 04:47
Last Modified: 12 Feb 2015 04:47
URI: http://eprints.manipal.edu/id/eprint/141831

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