Cardiac Autonomic Modulation in Cancer Patients as Assessed by Time Domain Measures of Heart Rate Variability

Bijoor, Shilpa N and *, Subbalakshmi NK and Banerjee, Sourjya (2015) Cardiac Autonomic Modulation in Cancer Patients as Assessed by Time Domain Measures of Heart Rate Variability. International Journal of Health Sciences and Research, 5 (2). pp. 194-198. ISSN 2249-9571

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Abstract

Introduction: Cancer is a leading cause of mortality. Recent research is probing into association between autonomic control and cancer. Aim & Objective: To find out the cardiac autonomic control in cancer patients compared to healthy subjects employing SDNN and E: I ratio. Method: 48 cancer patients and 48 healthy subjects (control) were studied. In them E: I ratio, SDNN, Heart rate (HR), Body mass index (BMI), Blood pressure were measured. E: I ratio, SDNN and HR was measured from one minute lead II electrocardiogram in supine position. Data was analyzed by Mann-Whitney test and unpaired t test. p value less than 0.05 was considered significant. Results: E: I ratio and HR was lower in cancer patients compared to control (p = 0.0001, 0.0003 respectively). SDNN did not differ significantly between cancer patients and control (p = 0.059). BMI, age, blood pressure did not differ significantly between cancer patients and control. Conclusion: As E:I ratio is a measure of fluctuation in parasympathetic activity and resting HR is mainly under vagal tone, it could be concluded that in cancer patients cardiovascular parasympathetic control is impaired compared to healthy subjects.

Item Type: Article
Uncontrolled Keywords: E: I ratio, SDNN, heart rate, vagal activity, cancer.
Subjects: Medicine > KMC Mangalore > Physiology
Medicine > KMC Mangalore > Radiotherapy and Oncology
Depositing User: KMCMLR User
Date Deposited: 13 Feb 2015 10:56
Last Modified: 13 Feb 2015 10:56
URI: http://eprints.manipal.edu/id/eprint/141875

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