Efficacy of Zincoderm G Cream Against Wound Infection by Pseudomonas Aeruginosa in Sprague-Dawley Rats

Satyam, SM and Bairy, Laxminarayana K and Musharaf, S and Fernandes, Donald J and Shashidhar, V (2015) Efficacy of Zincoderm G Cream Against Wound Infection by Pseudomonas Aeruginosa in Sprague-Dawley Rats. International Journal of Basic & Clinical Pharmacology, 4 (1). pp. 20-23. ISSN 2279-0780

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Background:Zincoderm G cream is a fixed dose combination of clobetasol, gentamicin and zinc. Studies have been carried out for efficacy of each component such as clobetasol and gentamicin in bacterial infections, but as fixed dose combination including zinc has not been reported yet. Hence, a study was planned to assess the efficacy of Zincoderm G cream in experimental wound infection by Pseudomonas aerugionosa.Methods:In the experiment a total of 18 Sprague-Dawley rats (male, pathogen free, 6-8 weeks old) were used. The rats were divided into three groups of six rats each. 25-30 mg of test drugs (Zincoderm G cream with or without zinc) was applied on Pseudomonas aeruginosa infected burn wound affected area of back of rats for 2 weeks. Bacterial infection was assessed by quantification of bacteria.Results:There was 80% mortality observed in P. aeruginosa infected toxic control(cream base) group. Whereas, only 40% mortality was seen in both Zincoderm G cream with/without zinc groups, which were inoculated with P. aeruginosa. Bacterial concentration (Number of colony forming unit/ml wound fluid) was significantly decreased (p<0.001) in P. aeruginosa infected rats treated with Zincoderm G cream with zinc when compared with P. aeruginosa infected control (untreated) rats.Conclusions:We found that Zincoderm G cream with zinc exhibited distinct killing profiles against P. aeruginosa.

Item Type: Article
Uncontrolled Keywords: Zincoderm G cream; Pseudomonas aeruginosa; Infection; Burn-wound
Subjects: Medicine > MMMC Manipal > Pharmacology
Medicine > KMC Manipal > Microbiology
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 13 Feb 2015 07:01
Last Modified: 13 Feb 2015 07:01
URI: http://eprints.manipal.edu/id/eprint/141904

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