Patel, IB and Bairy, KL and Bhat , SN and Shetty, DJ and Shalini, A (2015) Efficacy of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Muscle Relaxants and Neurotropic Drugs in Patients with Low Back Pain. American Journal of PharmTech Research, 5 (1). pp. 633-641. ISSN 2 2 4 9 - 338 7

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Abstract

To assess efficacy of different classes of drugs in therapy of low back pain.A prospective observational study was carried out over a period of 12 months in which a total of 300 patients with low back pain were enrolled and divided equally into three groups–group 1 (NSAIDs),group 2 (muscle relaxant ±NSAIDs) and group 3 (muscle relaxant ± NSAIDs ± neurotropic dru gs).Efficacy of drugs was assessed using oswestry low back disability questionnaire at baseline, 3 weeks and 6 weeks, and the disability index was calculated. There was a male predominance in the study population with a mean age of 39.76 ± 9.40 years. Mean percentage reduction in disability index was maximum in group 2 (54.66±9.85), followed by group 3 (51.33 ± 6.95) and group 1 (46.78 ± 10.12). A significant inter-group difference (p<0.05) was found. NSAIDs with muscle relaxants are more efficacious for low back pain as compared to other combinations.

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