Modulatory Role of Simvastatin against Aluminium Chloride-Induced Behavioural and Biochemical Changes in Rats

Nampoothiri, Madhavan and John, Jessy and Kumar, Nitesh and Mudgal, Jayesh and Kutty, Gopalan N and Rao, Mallikarjuna C (2015) Modulatory Role of Simvastatin against Aluminium Chloride-Induced Behavioural and Biochemical Changes in Rats. Behavioural Neurology, 2015. pp. 1-9.

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Abstract

Objectives. Aluminium, a neurotoxic agent in humans, has been implicated in the pathogenesis of neurodegenerative disorders. In this study, we examined the behavioral and biochemical effects of aluminium in rats with special emphasis on memory centres, namely, hippocampus and frontal cortex. Further, the effect of simvastatin treatment on aluminium intoxication was evaluated. Methods. Rats were exposed to aluminium chloride (AlCl3) for 60 days. Simvastatin (10mg/kg/p.o.) and rivastigmine (1mg/kg/p.o.) were administered daily prior to AlCl3. Behavioral parameters were assessed using Morris water maze test and actophotometer followed by biochemical investigations, namely, acetylcholinesterase (AChE) activity, TNF-

Item Type: Article
Subjects: Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 17 Feb 2015 04:18
Last Modified: 17 Feb 2015 04:18
URI: http://eprints.manipal.edu/id/eprint/141957

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