Novel pH-sensitive IPNs of polyacrylamide-g-gum ghatti and sodiumalginate for gastro-protective drug delivery

Nayak, Usha and Mutalik, Srinivas (2015) Novel pH-sensitive IPNs of polyacrylamide-g-gum ghatti and sodiumalginate for gastro-protective drug delivery. International Journal of Biological Macromolecules, 75. pp. 133-143. ISSN 0141-8130

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Abstract

This article reports the development of pH-sensitive interpenetrating polymer network (IPN) microbeadsusing polyacrylamide-grafted-gum ghatti (PAAm-g-GG) and sodium alginate (SA) for gastro-protectivecontrolled delivery of ketoprofen. We have synthesized PAAm-grafted-GG copolymer under microwaveirradiation using cerric ammonium nitrate as reaction initiator; further, the PAAm-g-GG was convertedto pH-sensitive copolymer through alkaline hydrolysis. Sophisticated instrumentation techniques wereused to characterize PAAm-g-GG. The IPN microbeads of PAAm-g-GG and SA, pre-loaded with ketopro-fen were prepared by dual crosslinking using Ca2+ions and glutaraldehyde (GA). The IPN microbeadsdemonstrated excellent pH-sensitive behavior as noted in the pulsatile swelling test and scanning elec-tron microscopy. IPN microbeads also showed larger amount of drug release in buffer solution of pH 7.4as compared to drug release in solution of pH 1.2. The in vivo pharmacokinetic, pharmacodynamic andstomach histopathology studies conducted on wistar rats confirmed the pH-sensitive controlled releaseof ketoprofen; IPN microbeads retarded the drug release in stomach resulting in reduced adverse effectsof ketoprofen.

Item Type: Article
Uncontrolled Keywords: Gastro-protective; Drug targeting; Interpenetrating polymer network; Graft copolymer; In vivo studies.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutics
Depositing User: KMC Manipal
Date Deposited: 17 Feb 2015 04:26
Last Modified: 17 Feb 2015 04:26
URI: http://eprints.manipal.edu/id/eprint/141960

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