Study of the reproducibility of the 2004 World Health Organization classification of urothelial neoplasms

Sharma, Pallavi and Kini, Hema and Pai, Radha R. and Sahu, Kaushalya K. and Kini, Jyoti R. (2015) Study of the reproducibility of the 2004 World Health Organization classification of urothelial neoplasms. Indian Journal of Pathology and Microbiology, 58 (1). pp. 59-61.

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Abstract

The aim of the study was to evaluate urinary bladder biopsies showing papillary urothelial neoplastic lesions based on the 2004 WHO/ISUP classifi cation of Urothelial Neoplasms of the Urinary Bladder, to assess the reproducibility of the bladder carcinoma grade. Fifty consecutive transurethral tumor resection biopsies were evaluated by four pathologists independently. The fi nal diagnoses of each pathologist were subjected to statistical analysis to assess the degree of interobserver variability and reproducibility of this classifi cation. Signifi cant interobserver variation was found in the reporting of urothelial neoplasms. In 22 instances there was difference in opinion between PUNLMP and low-grade carcinoma, and in 59 instances between low and high grade carcinoma. The 4 observers never unanimously agreed on the diagnosis of PUNLMP.

Item Type: Article
Uncontrolled Keywords: Histologic grading, urinary bladder, World Health Organization/ International Society of Urological Pathology classifi cation
Subjects: Medicine > KMC Mangalore > Pathology
Depositing User: KMCMLR User
Date Deposited: 18 Feb 2015 06:40
Last Modified: 18 Feb 2015 06:40
URI: http://eprints.manipal.edu/id/eprint/141970

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