Prathibha, M and Tatiyana, M and Bairy, KL and Adiga, S (2015) Wound healing activity of oil extract of tectona grandis leaves in wistar rats. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 6 (1). pp. 423-428. ISSN 0975-8585

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Abstract

Frontal leaves of Tectona grandis are used traditionally for the treatment of variety of wounds. Scientific data is not available regarding the wound healing activity of oil extract of frontal leaves of Tectona grandis. Hence this study was undertaken to investigate the effect of topical application of oil extract of frontal leaves of Tectona grandis on incision and excision wound models in rats. 4 groups (control, vehicle control - coconut oil, standard - aloe vera, test - oil extract of Tectona grandis leaves) of wistar rats were used each for excision and incision wound model. Parameters studied were wound breaking strength in incision wound model and percentage of wound contraction and period of epithelisation in excision wound model. Results showed a significant increase in the breaking strength (p<0.001) in incision wound model; decrease in period of epithelisation (p<0.01) and increase in wound contraction rate (p<0.001) in excision wound model in the test group when compared to control group. Therefore, this study ascertains the wound healing activity of Tectona grandis leaves and it substantiates the use of frontal leaves of Tectona grandis in Ayurveda for treatment of wounds.

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