Correlation of epicardial adipose tissue in metabolic syndrome with anthropometric and biochemical parameters

Vidyasagar, Sudha and Tonse, Mubarakunnisa and Shetty, Ranjan K and Chogtu, Bharti and Bairy, KL (2015) Correlation of epicardial adipose tissue in metabolic syndrome with anthropometric and biochemical parameters. International Journal of Advanced Research, 3 (2). pp. 412-419. ISSN 2320-5407

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Abstract

Background: Epicardial fat, a true visceral adipose tissue, is highly insulin resistant and deposited around the heart. Objectives: To compare the epicardial fat thickness of subjects with metabolic syndrome with normal individuals and to correlate epicardial fat thickness with various parameters of metabolic syndrome. Methods and Results: A case control study involving 43 cases of metabolic syndrome and equal number of controls (age matched) was conducted at tertiary care hospital from October 2010 to July 2012. All the subjects underwent anthropometry (waist circumference, waist to hip ratio, BMI) and biochemical investigation consisting of fasting blood glucose and fasting lipid profile. Epicardial fat thickness was measured in all the subjects. Results: There was increased epicardial fat thickness in cases (3.1±1.1mm) of metabolic syndrome as compared to controls (2.3±0.9mm). Epicardial fat thickness showed significant correlation with age (p = 0.004, r= 0.43), diabetes (p=0.051), Triglycerides (p = 0.036, r =0.324), LDL-C (p=0.023, r =0.344), BMI in males (p=0.038, r=0.317) and Waist-Hip ratio in females (p=0.008, r=0.407). Conclusion: Patients with metabolic syndrome have higher amount of epicardial adipose tissue deposition. Hence, epicardial fat can be used as a tool for screening subjects with metabolic syndrome.

Item Type: Article
Subjects: Medicine > KMC Manipal > Cardiology
Medicine > KMC Manipal > Medicine
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 03 Mar 2015 04:24
Last Modified: 03 Mar 2015 04:24
URI: http://eprints.manipal.edu/id/eprint/142066

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