Effects of botropase on clotting factors in healthy human volunteers

Shenoy, Ashok K and *, Ramesh. K. V and Chowta, Mukta N and Adhikari, Prabha and *, Rathnakar UP (2014) Effects of botropase on clotting factors in healthy human volunteers. Perspectives in Clinical Research, 5 (2). pp. 71-74. ISSN 2229-3485

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Abstract

Objective: To evaluate the effects of botropase on various clotting factors in human volunteers. Materials and Methods: It was a prospective open label study conducted on human healthy volunteers. After the baseline screening, subjects fulfilling inclusion criteria were enrolled. On the study day, 1 ml of botropase was administered intravenously and after an hour same dose of botropase (1 ml) was given by intramuscular (IM) route. The efficacy and safety parameters were monitored up to 72 h from the time of intravenous (IV) administration. Results: A total of 15 volunteers, belonging to 24-35 years of age were included in the study. Botropase significantly reduced the plasma level of fibrinogen and fibrin degradation products after 5 min of IV administration (P < 0.05). In addition, factor X was observed to reduce constantly by botropase administration suggesting enhanced turnover between 5 and 20 min of IV administration. Although botropase reduced clotting and bleeding time in all the volunteers, the data remains to be statistically insignificant. Conclusion: Present study demonstrated the safety and efficacy of botropase in human healthy volunteers. The study has shown that it is a factor X activator and reduces effectively clotting and bleeding time.

Item Type: Article
Uncontrolled Keywords: Botropase, clotting factors, fibrinogen, hemocoagulase
Subjects: Medicine > KMC Mangalore > Pharmacology
Medicine > KMC Mangalore > Medicine
Depositing User: KMCMLR User
Date Deposited: 04 Mar 2015 07:54
Last Modified: 04 Mar 2015 07:54
URI: http://eprints.manipal.edu/id/eprint/142089

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