Prevalence of Hepatitis A virus (HAV) and Hepatitis E virus (HEV) in the patients presenting with acute viral hepatitis

Joon, Annu and Rao, Pooja and Shenoy, Suchitra M and Baliga, Shrikala (2015) Prevalence of Hepatitis A virus (HAV) and Hepatitis E virus (HEV) in the patients presenting with acute viral hepatitis. Indian Journal of Medical Microbiology, 33 (S1). S102-S105. ISSN 0255-0857

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Background: Hepatitis A virus (HAV) and Hepatitis E virus (HEV) are both enterically transmitted, resulting in acuteviral hepatitis (AVH) in developing countries. They pose major health problems in our country. This study was doneto determine prevalence of HAV and HEV in patients presenting with AVH and the co-infection of HAV and HEV inthese patients. Materials and Methods: A cross-sectional study of 2-years duration was conducted in the Departmentof Microbiology, KMC, Mangalore. A non-random sampling of 958 patients presenting with AVH was considered in the study. On the basis of history, serum samples were analysed for IgM anti-HAV and IgM anti-HEV for the detection ofHAV and HEV, respectively using commercially available ELISA kits. Data collected was analysed by using StatisticalPackage for the Social Sciences (SPSS) version 11.5. Results: The seroprevalence of HAV- and HEV-positive patientswere 19.31% and 10.54%, respectively. The seroprevalence of both HAV and HEV in patients with acute viral hepatitiswas 11.5%. The prevalence of HAV and HEV among males (68% and 31%) was higher than in females (31% and 20%)and was predominantly seen among young adults. These infections were predominantly seen during end of monsoonsand beginning of winter. Conclusion: Though the prevalence of HAV is much higher than that of HEV, co-infectionrate of 11.5% mandates the screening for HEV which will be of immense importance in pregnant women and improvinglevels of personal hygiene among higher socio-economic population. These data will be essential for planning of futurevaccination strategies and for better sanitation programme in this part of the country.

Item Type: Article
Uncontrolled Keywords: Acute viral hepatitis, co-infection, Hepatitis A Virus, Hepatitis E Virus, prevalence
Subjects: Medicine > KMC Mangalore > Microbiology
Depositing User: KMCMLR User
Date Deposited: 06 Mar 2015 07:06
Last Modified: 06 Mar 2015 07:06

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