Dumb-bell Shaped Poorly Differentiated Pelvic Synovial Sarcoma with Molecular Confirmation: A Rare Presentation of an Uncommon Disease Entity

Hasan, Roumina and Kumar, Sandeep and Rao, Lakshmi (2013) Dumb-bell Shaped Poorly Differentiated Pelvic Synovial Sarcoma with Molecular Confirmation: A Rare Presentation of an Uncommon Disease Entity. Indian Journal of Pathology and Microbiology, 56 (4). pp. 396-398.

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Abstract

Pelvic localization of synovial sarcoma is a rare phenomenon and to the best of our knowledge its presentation as a large “dumb-bell”-shaped abdomino-pelvic mass showing extension to the thigh has never been reported in the literature. We report a case of a young adult presenting with retention of urine and was found to have a large abdomino-pelvic mass causing bony destruction and compression of pelvic viscera. A biopsy revealed a cellular tumor composed of spindle to oval cells arranged in a hemangiopericytomatous pattern. Histopathology was suggestive of poorly differentiated synovial sarcoma. Immunohistochemistry (IHC) was positive for vimentin, CD 99, Bcl2, Mic2 and focally for EMA and negative for CD 34, CK, desmin, synaptophysin, and WT1. Due to equivocal IHC fi ndings molecular analysis was done which confi rmed the diagnosis as synovial sarcoma.

Item Type: Article
Uncontrolled Keywords: Immunohistochemistry; Molecular analysis; Pelvic synovial sarcoma; Soft tissue sarcomas
Subjects: Medicine > KMC Manipal > Pathology
Medicine > KMC Manipal > Radiology
Depositing User: KMC Manipal
Date Deposited: 07 Mar 2015 10:37
Last Modified: 07 Mar 2015 10:37
URI: http://eprints.manipal.edu/id/eprint/142126

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