Nalini, K and Shenoy, Vijetha Belle and Kini, Pushpa G and Jacob, Prince and Rao, Pragna (2015) Novel Urinary and Plasma Biochemical Findings in a Child with Recurrent Respiratory Infections. Asia Pacific Journal of Research, 1 (14). pp. 26-30. ISSN 2347-4793

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Abstract

Lysinuric protein intolerance is rare autsomal recessive disorder, characterized byinability of the intestine to absorb themand increased excretion of lysine, arginine and ornithine by kidneys. Infants with this disease do not show symptoms as long as they are breast-fed. They develop symptoms when fed with protein rich food. This disease involves almost all organs of the body. In this case one year old child presented with recurrent respiratory infections and high performance liquid chromatography showed increased levels of lysine arginine and ornithine amino acids in urine sample and consequent decreased levels of mentioned amino acids in plasma, indicating the probable diagnosis of Lysinuric protein intolerance. This child improved when diet is modified with low protein. Thus if a child during the weaning period presents with failure to thrive, recurrent respiratory infections there may be a possibility of Lysinuric protein intolerance disease.

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