Evaluation of Intravaginal Misoprostol for Cervical Priming in First Trimester (Pregnancy Termination)

Pal, Sharan J. and *, Usha Sadasivan and Mulki, Shilpa and *, Jagadevi S (2015) Evaluation of Intravaginal Misoprostol for Cervical Priming in First Trimester (Pregnancy Termination). Journal of Medical Science and Clinical Research, 03 (02). pp. 4277-4284. ISSN (e)-2347-176x

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Abstract

Women often resort to surgical abortion because they lack information on contraception or fear the side effects of medical methods of abortions. A safe medical or combined medical and surgical method is the need of hour and would save many lives. An effective cervical priming agent would aid surgical abortions or would be effective alone. Objective: To compare various dosage, regime and safety of intravaginal misoprostol (posterior fornix) prior to surgical evacuation for cervical priming in first trimester. Materials & methods: It was a prospective study which consisted of 75 patients divided into 3 groups, 25 patients each, with control group of 75 patients who did not have cervical priming .Both groups underwent surgical evacuation. Group 1: 200 microgram of misoprostol inserted, 6 hours prior to procedure. Group 2: 200 microgram of misoprostol inserted, 12 hours prior to procedure. Group3: 400microgram of misoprostol inserted, 12 hours prior to procedure. Results: Successful priming defined as passage of no.10 Hegar’s dilator without resistance was noted in 96% in group 3 compared to 88% in group 2 and 60% in group 1.Success rate was significant in 8-12 weeks period of gestation. Only 4% needed operative dilation in group 3 compared to 16% in group 2 and 36% in group 1. Nausea, vomiting and abdominal cramps were noted in 12% in group 1, 4% in group 2 and none in group 3. Blood loss was less in group 3 compared to other groups. Conclusion: Misoprostol has proved to be a safe , cost effective, easily acceptable cervical priming agent in the first trimester termination of pregnancy in the dose of 400micrograms vaginally 12hours prior to surgical evacuation .

Item Type: Article
Uncontrolled Keywords: Misoprostol, abortion, cervical priming, vacuum aspiration.
Subjects: Medicine > KMC Mangalore > Obstetrics & Gynaecology
Depositing User: KMCMLR User
Date Deposited: 16 Mar 2015 10:48
Last Modified: 16 Mar 2015 10:48
URI: http://eprints.manipal.edu/id/eprint/142185

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