Design, synthesis, antioxidant and anticancer activity of novel pyrazole derivatives

Mubeen, Muhammad and Kini, Suvarna G and Pai, KSR (2015) Design, synthesis, antioxidant and anticancer activity of novel pyrazole derivatives. Der Pharma Chemica, 7 (2). pp. 215-223. ISSN 0975-413X

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Docking studies of a series of pyrazole derivatives were performed with the help of VLife MDS 4.2 software using Epidermal Growth Factor Receptor kinase domain (PDB ID: 1M17) as a target. Docked compounds were analyzed for hydrogen bonding, hydrophobic bonding and vander Waal’s interactions. Based on the docking results, novel pyrazole derivatives were synthesized and characterized by IR, 1H NMR,13CNMR and Mass spectroscopy. These compounds were screened for antioxidant activity by DPPH radical scavenging activity and anticancer activity against breast cancer cell line (MCF-7) and lung cancer cell line (A549) with MTT assay. Compounds P9, P21 and P22 showed significant antioxidant activity. Compounds P1, P6, P7, P11 and P12 showed significant anticancer activity against MCF-7 and A549 cell lines which was comparable to the positive control doxorubicin.

Item Type: Article
Uncontrolled Keywords: Anticancer; Antioxidant; Pyrazole, Docking; MTT assay.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 19 Mar 2015 09:29
Last Modified: 19 Mar 2015 09:29

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