Patel, IB and Bairy, KL and Bhat, SN and Shetty, DJ and Chogtu, Bharti (2015) Adverse drug reactions and cost effectiveness of non-steroidal antiinfl ammatory drugs, muscle relaxants, and neurotropic drugs in patients with low back pain. International Journal of Basic & Clinical Pharmacology, 4 (2). pp. 273-277. ISSN 2319-2003
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Abstract
Background: The objective was to evaluate the adverse drug reactions (ADRs) and cost effectiveness of different classes of drugs in therapy of low back pain. Methods: A prospective observational study was carried out over a period of 12 months (November 2012 to November 2013) in which a total of 300 patients with low back pain were enrolled and divided equally into three groups – Group 1 (nonsteroidal anti-infl ammatory drugs [NSAIDs]), Group 2 (NSAIDs ± muscle relaxant), and Group 3 (NSAIDs ± muscle relaxant ± neurotropic drugs). Any ADR developed after the initiation of treatment at 3 weeks and 6 weeks was noted. Prescription cost per day was also calculated. Results: There was a male predominance in the study population with a mean age of 39.76±9.40 years. A total of 262 ADRs were noted among which most were seen in Group 3 (119 ADRs). Gastritis was the most common ADR in Group 1. Drowsiness was the most common ADR in Group 2 (30%) and 3 (46%). Prescription cost per day was highest in Group 3 (30.28±11.24 Indian Rupee [INR]) followed by Group 2 (25.92±8.66 INR) and Group 1 (12.22±3.38 INR). Conclusion: Patient on combination of three drugs (NSAIDs, muscle relaxants, and neurotropic agents) had maximum ADRs and their prescription cost per day was highest among the three groups.
Item Type: | Article |
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Uncontrolled Keywords: | Adverse drug reactions; Cost effectiveness; Low back ache; Muscle relaxant; Neurotropic drugs; Non-steroidal anti-infl ammatory drugs. |
Subjects: | Medicine > KMC Manipal > Orthopaedics Medicine > KMC Manipal > Pharmacology |
Depositing User: | KMC Manipal |
Date Deposited: | 06 Apr 2015 04:52 |
Last Modified: | 06 Apr 2015 04:52 |
URI: | http://eprints.manipal.edu/id/eprint/142343 |
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