Adverse drug reactions and cost effectiveness of non-steroidal antiinfl ammatory drugs, muscle relaxants, and neurotropic drugs in patients with low back pain

Patel, IB and Bairy, KL and Bhat, SN and Shetty, DJ and Chogtu, Bharti (2015) Adverse drug reactions and cost effectiveness of non-steroidal antiinfl ammatory drugs, muscle relaxants, and neurotropic drugs in patients with low back pain. International Journal of Basic & Clinical Pharmacology, 4 (2). pp. 273-277. ISSN 2319-2003

[img] PDF
210.Adverse drug reactions and cost effectiveness of NSAIDS.pdf - Published Version
Restricted to Registered users only

Download (191kB) | Request a copy

Abstract

Background: The objective was to evaluate the adverse drug reactions (ADRs) and cost effectiveness of different classes of drugs in therapy of low back pain. Methods: A prospective observational study was carried out over a period of 12 months (November 2012 to November 2013) in which a total of 300 patients with low back pain were enrolled and divided equally into three groups – Group 1 (nonsteroidal anti-infl ammatory drugs [NSAIDs]), Group 2 (NSAIDs ± muscle relaxant), and Group 3 (NSAIDs ± muscle relaxant ± neurotropic drugs). Any ADR developed after the initiation of treatment at 3 weeks and 6 weeks was noted. Prescription cost per day was also calculated. Results: There was a male predominance in the study population with a mean age of 39.76±9.40 years. A total of 262 ADRs were noted among which most were seen in Group 3 (119 ADRs). Gastritis was the most common ADR in Group 1. Drowsiness was the most common ADR in Group 2 (30%) and 3 (46%). Prescription cost per day was highest in Group 3 (30.28±11.24 Indian Rupee [INR]) followed by Group 2 (25.92±8.66 INR) and Group 1 (12.22±3.38 INR). Conclusion: Patient on combination of three drugs (NSAIDs, muscle relaxants, and neurotropic agents) had maximum ADRs and their prescription cost per day was highest among the three groups.

Item Type: Article
Uncontrolled Keywords: Adverse drug reactions; Cost effectiveness; Low back ache; Muscle relaxant; Neurotropic drugs; Non-steroidal anti-infl ammatory drugs.
Subjects: Medicine > KMC Manipal > Orthopaedics
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 06 Apr 2015 04:52
Last Modified: 06 Apr 2015 04:52
URI: http://eprints.manipal.edu/id/eprint/142343

Actions (login required)

View Item View Item