Formulation and evaluation of the hydroalcoholic extract of Caesalpinia Pulcherrima (Stem bark) on wound healing model in wistar rats

Patil, Navin and Vaishnav, Rajdip Lalitkumar and Thanusubramanian, Harish and Holla, Sadhana N and Manohar, Hasitha Diana and Bairy, KL (2015) Formulation and evaluation of the hydroalcoholic extract of Caesalpinia Pulcherrima (Stem bark) on wound healing model in wistar rats. International Journal of Advanced Research, 3 (3). pp. 648-654. ISSN 2320-5407

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Abstract

Caesalpinia Pulcherrima is commonly known as a Peacock’s pride. Plant is enriched with flavonoids, triterpenoids, tannins and phenolic compounds. Wound healing process is complex, and involves many cellular intermediate pathways. Two models were adopted to evaluate the wound healing activity of Caesalpinia pulcherrima (Stem bark): excision and incision wound model in wistar rats. Hydroalcoholic extract of C. pulcherrima (stem bark) was incorporated in to the lipophilic base ointment to achieve the 10 and 20% w/w concentration. In excision and incision skin wound models, herbal medicated ointment formulation was applied topically for 21 days and 10 days respectively after the induction of wound injury. In excision wound model, high dose (20% w/w) of ointment was found to be more statistically significant (p<0.05) and (p<0.001) on wound contraction on 7th and 14thday respectively when compared to the control group. Low dose (10% w/w) group was significant (p<0.05) but less significant as compared to high dose group statistically. In incision wound model, high dose group (20% w/w) showed maximum tensile strength (502.50) and was found statistically significant (p<0.01) when compared with the control group.

Item Type: Article
Uncontrolled Keywords: Caesalpinia Pulcherrima; ointment, excision; incision; wound healing.
Subjects: Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 09 Apr 2015 04:27
Last Modified: 09 Apr 2015 04:27
URI: http://eprints.manipal.edu/id/eprint/142380

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