Malignant Phyllodes with Osteosarcomatous Differentiation – A Case Report

Subramaniam, Jegan and Nair, Rajesh P and Nayal, Bhavna and Rao, Lakshmi (2014) Malignant Phyllodes with Osteosarcomatous Differentiation – A Case Report. Medico Research Chronicles, 1 (2). pp. 193-196. ISSN 2394-3971

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Abstract

Introduction: Malignant phyllodes tumor is a rare and aggressive neoplasm, which presents as breast lump and is detected on routine examination in premenopausal women. Heterologous differentiation is uncommon in these tumors. Owing to its rare occurrence, very few treatment protocols have been formulated for these cases posing a surgical dilemma.Presentation of Case: For a better understanding of the pathogenesis and prognosis of these tumors we discuss here the clinical profile of a 49 year-old lady with metastatic phyllodes tumor of the breast with osteosarcomatous differentiation.Discussion: Malignant phyllodes with osteosarcomatous differentiation are highly aggressive and extremely rare constituting 1.3% of all breast cancers. It has been hypothesized that malignant change of metaplastic stromal result in these neoplasms.Conclusion: To conclude, malignant phyllodes are a rare entity. Osteosarcomatous differentiation is almost unheard of and indicates an aggressive biological behavior. Accurate diagnosis and timely surgical management is essential to prevent progression of the disease and improve survival.

Item Type: Article
Uncontrolled Keywords: Breast tumor; Malignant phyllodes tumor; Osteosarcomatous features; Infiltrating ductal carcinoma
Subjects: Medicine > KMC Manipal > Pathology
Medicine > KMC Manipal > Surgery
Depositing User: KMC Manipal
Date Deposited: 15 Apr 2015 07:06
Last Modified: 15 Apr 2015 07:06
URI: http://eprints.manipal.edu/id/eprint/142437

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