*, Subbalakshmi NK and Adhikari, Prabha and *, Vinaya Poornima and Rao , Sathyanrayana KN (2015) Correlates of SDNN heart rate variability in healthy subjects and subjects with type 2 diabetes mellitus. International Journal of Biomedical And Advance Research, 6 (3). pp. 208-211. ISSN 2229-3809
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Abstract
Introduction: Standard deviation of R-R intervals (SDNN) predicts mortality in variety of clinical conditions. But little is known about correlates of SDNN. Objective: To investigate correlates of SDNN in healthy subjects and with type 2 diabetes. Materials and Methods: 115 male subjects with type 2 diabetes and 87 controls were studied. In them heart rate (HR), blood pressure (BP), body mass index (BMI), Q -Tc and SDNN were measured. Pearson correlation coefficient and unpaired t test were used for data analysis. P < 0.05 was considered significant. Results: In controls, SDNN was negatively correlating with age and HR (p < 0.05, <0.001 respectively). In subjects with type 2 diabetes, SDNN was negatively correlating with HR, diastolic blood pressure, Q-Tc and duration of diabetes (p < 0.0001, < 0.01, = 0.014, < 0.05 respectively); and was positively correlating with BMI (p < 0.05). Conclusion: Higher HR, DBP, prolonged Q-T interval and duration of diabetes are associated with reduced SDNN in subjects with type 2 diabetes. In them BMI could be a confounding factor while assessing cardiac autonomic dysfunction employing SDNN. In healthy subjects high HR and age are associated with reduced SDNN.
Item Type: | Article |
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Uncontrolled Keywords: | SDNN, heart rate, Q-Tc, blood pressure, duration of diabetes |
Subjects: | Medicine > KMC Mangalore > Physiology Medicine > KMC Mangalore > Radio Diagnosis and Imaging Medicine > KMC Mangalore > Medicine |
Depositing User: | KMCMLR User |
Date Deposited: | 16 Apr 2015 11:23 |
Last Modified: | 16 Apr 2015 11:23 |
URI: | http://eprints.manipal.edu/id/eprint/142451 |
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