Synthesis and in vitro biological evaluation of new pyrazole chalcones and heterocyclic diamides as potential anticancer agents

Rai, Sankappa U and Isloor, Arun M and Shetty, Prakash and Pai, KSR and Fun, Hoong-Kun (2015) Synthesis and in vitro biological evaluation of new pyrazole chalcones and heterocyclic diamides as potential anticancer agents. Arabian Journal of Chemistry, 8. pp. 317-321. ISSN 1878-5352

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Abstract

Synthesis and characterization of new heterocyclic pyrazole chalcones (4a–e) and diamide (6a–e) derivatives are described. Pyrazole chalcones were synthesized by the reaction of pyrazole aldehydes and suitable aromatic ketones. Diamides were synthesized by the reaction of phthalic acid and amines. Newly synthesized compounds were characterized by spectral studies and their biological activity was assessed in vitro using MCF-7 (human breast adenocarcinoma)and HeLa (human cervical tumor cells) cell lines. Few of the synthesized molecules inhibited the growth of the human breast cancer cell lines and human cervical tumor cell lines at low micromolar to nanomolar concentrations.

Item Type: Article
Uncontrolled Keywords: MCF 7; HeLa; EDCI; HOBt; Diamide
Subjects: Engineering > MIT Manipal > Chemistry
Pharmacy > MCOPS Manipal > Pharmacology
Engineering > MIT Manipal > Printing and Media
Depositing User: MIT Library
Date Deposited: 20 Apr 2015 09:57
Last Modified: 20 Apr 2015 09:57
URI: http://eprints.manipal.edu/id/eprint/142487

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