Grape seed extract and Zinc Containing Nutritional Food Supplement Delays Onset and Progression of Streptozocin-induced Diabetic Cataract in Wistar Rats

Satyam, Shakta Mani and Bairy, KL and Pirasanthan, Rajadurai and Vaishnav, Rajdip Lalit (2015) Grape seed extract and Zinc Containing Nutritional Food Supplement Delays Onset and Progression of Streptozocin-induced Diabetic Cataract in Wistar Rats. Journal of Food Science and Technology, 52 (5). pp. 2824-2832.

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Abstract

Prevention of hyperglycemia and enhancement of antioxidant defense mechanisms remain major goals in the treatment of diabetic cataract. Earlier, we reported strong antihyperglycemic and in vitro antioxidant potential of the combined formulation of grape seed extract and Zincovit tablets.Therefore, the current study was designed to investigate effects of combined formulation of grape seed extract and Zincovit tablets against streptozocin-induced diabetic cataract in Wistar rats. Adult Wistar rats were selected and diabetes was induced by streptozocin (35 mg/kg, i.p) and divided into four groups (group II-V). The normal control (group I) and streptozocin-induced diabetic cataract control rats received only vehicle. Groups III, IV and V animals received orally 40, 80 and 160 mg/kg of combined formulation of Zincovit tablets with grape seed extract respectively for a period of 150 days. The biochemical pathways involved in the pathogenesis of cataract such as oxidative stress, polyol pathway and alterations in adenosine triphosphate, glucose-6-phosphate dehydrogenase and blood glucose were investigated,to understand the possible mechanism of action of combined formulation of grape seed extract and Zincovit tablets.Rats treated with combined formulation of grape seed extract and Zincovit tablets delayed the progression of diabetic cataract as well as it showed significant alterations in oxidative stress markers along with blood glucose, aldose reductase,glucose-6-phosphate dehydrogenase and adenosine triphosphate level in lens. Over all, the results suggest that single combined formulation of grape seed extract and Zincovit tablets may be of great value in delaying diabetic cataract of human subjects as nutritional food supplement.

Item Type: Article
Uncontrolled Keywords: Diabetic cataract; Oxidative stress; Polyol pathway; Adenosine triphosphate; Grape seed extract; Zincovit tablets
Subjects: Medicine > MMMC Manipal > Pharmacology
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 23 Apr 2015 05:05
Last Modified: 23 Apr 2015 05:05
URI: http://eprints.manipal.edu/id/eprint/142499

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