Advanced glycation end products in the pathogenesis of diabetic retinopathy: a review

Gaonkar, Bhaskar and Prabhu, Krishnananda (2015) Advanced glycation end products in the pathogenesis of diabetic retinopathy: a review. Asian Journal of Pharmaceutical Research, 5 (2). pp. 134-142. ISSN 2231 – 363X

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Abstract

Advanced glycation end products are a group of biochemical species formed by the chronic exposure of vital biomolecules to hyperglycemia. All events leading to diabetic retinopathy such as, adhesion of leukocytes and monocytes to capillary endothelial cells, apoptosis of endothelial cells and pericytes, dismantling of blood retinal barrier, increased expression of pro-angiogenic factors and decreased the expression of anti-angiogenic factors in the retinal endothelial cell are linked to an increased formation of advanced glycation end products. Expression of receptors for the advanced glycation end products and its gene polymorphism are found to have a major implication in the development and progression of diabetic retinopathy. Soluble extracellular ligand binding domains of these receptors called as sRAGEs that circulate freely in plasma are shown to scavenge advanced glycation end products and prevent damages. So there lies a large scope for research with respect to the role of sRAGE in the treatment and management of diabetic retinopathy.

Item Type: Article
Uncontrolled Keywords: Diabetic retinopathy; advanced glycation end products; receptors for advanced glycation end products; angiogenesis.
Subjects: Medicine > KMC Manipal > Biochemistry
Depositing User: KMC Manipal
Date Deposited: 24 Apr 2015 09:24
Last Modified: 24 Apr 2015 09:24
URI: http://eprints.manipal.edu/id/eprint/142509

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