Risk of oral cancer associated with gutka and other tobacco products: A hospital‑based case–control study

Shetty, Bharatesh K and Binu, VS (2015) Risk of oral cancer associated with gutka and other tobacco products: A hospital‑based case–control study. Journal of Cancer Research and Therapeutics, 11 (1). pp. 199-203. ISSN 0973-1482

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Background: Although tobacco deaths rarely make headlines, tobacco kills one person every six seconds. Tobacco kills a third to half of all people who use it, on average 15 years prematurely. Aim of the Study: To study the risk of oral cancer associated with gutka consumption and other tobacco products. Objective: (1) To find the association between gutka consumption and oral cancer. (2) To study the association between oral cancer and other tobacco products. Methodology: A case‑control study of 134 cases and 268 controls, over a period of 5 months, from March 2013 to July 2013, was carried out at the Kasturba medical hospital in Manipal, India. The participants were personally interviewed by the investigator using a structured questionnaire on consumption of tobacco, poly‑ingredient dip products, alcohol, dietary practices, oral hygiene practices and demographic status. Results: Univariate logistic regression followed by multivariate logistic regression was done for identifying the risk factors and adjusted for the confounding variables. Analysis showed that gutka (<0.001, OR = 5.1 95% CI = 2.0‑10.3), chewing tobacco (P < 0.001, OR = 6.0 95% CI = 2.3‑15.7), supari (P < 0.001, OR = 11.4 95% CI = 3.4,38.2), betel quid (P < 0.001, OR = 6.4 95% CI = 2.6‑15.5), bidi (P < 0.05, OR = 2.3 95% CI = 1.1‑4.8) and alcohol (P < 0.001, OR = 3.7 95%CI = 1.8‑7.5) had strong association with oral cancer upon adjustment. Conclusion: The study provided strong evidence that gutka, supari, chewing tobacco, betel quid, bidi and alcohol are independent risk factors for oral cancer.

Item Type: Article
Uncontrolled Keywords: Case‑control; tobacco; oral dip products; oral cancer; smoking; gutka.
Subjects: Departments at MU > Public Health
Departments at MU > Statistics
Depositing User: KMC Manipal
Date Deposited: 30 Apr 2015 07:14
Last Modified: 30 Apr 2015 07:14
URI: http://eprints.manipal.edu/id/eprint/142572

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