Nayak, Rajesh R and Kamath, Gurudutt M and Kamath, Manjunath M and Kamath, Ajay R and D’Souza, Susan and *, Roopashree (2013) Ocular Surface Squamous Neoplasia in Xeroderma Pigmentosum. Online Journal of Health and Allied Sciences, 12 (3). pp. 1-2. ISSN 0972-5997

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Abstract

Xeroderma pigmentosum (XP) is a rare genetic disorder associated with multiple oculocutaneous and neurological manifestations. It occurs due to deficiency of the enzymes responsible for repairing ultraviolet radiationinduced DNA damage. Persistence of un-repaired DNA results in somatic mutations, leading to neoplasia of the skin and ocular surface. As this condition is rare, only isolated case reports of XP with ocular surface squamous neoplasia (OSSN) are found in literature.

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