Formation of Substituted Propanenitrile during Biginelli Type Reaction of Tosyloxy Benzaldehyde with Malononitrile: Synthesis and Crystal Structure Determination.

Shubhalaxmi, . and Kumar, Chidan CS and Fun, Hoong-Kun and Bhat, Subrahmanya K (2015) Formation of Substituted Propanenitrile during Biginelli Type Reaction of Tosyloxy Benzaldehyde with Malononitrile: Synthesis and Crystal Structure Determination. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 6 (3). pp. 1288-1233. ISSN 0975-8585

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Abstract

Reaction of active methylene compound with an aldehyde and thiourea under Biginelli conditions reported to yield dihydropyrimidine derivatives in good yield. Herein we report a special case wherein the isolated product was propanenitrile derivative resulting from Knoevenagel condensation of malononitrile with the aldehyde. The structure of the product was confirmed by single crystal X-ray diffraction studies

Item Type: Article
Uncontrolled Keywords: Biginelli type reaction; Knoevenagel condensation; Crystal structure; Spectral characterization.
Subjects: Engineering > MIT Manipal > Chemistry
Depositing User: MIT Library
Date Deposited: 15 May 2015 10:35
Last Modified: 15 May 2015 10:35
URI: http://eprints.manipal.edu/id/eprint/142650

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