Oral Ingestion of Spondias pinnata Bark Extract Trim Down Severity of Small Intestinal Mucositis in Etoposide Treated Rats

Reddy , Sudarshan C and Shetty, Beena V and Rao, Gayathri M (2015) Oral Ingestion of Spondias pinnata Bark Extract Trim Down Severity of Small Intestinal Mucositis in Etoposide Treated Rats. Cancer Science & Therapy, 7 (2). 030-033.

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Abstract

Chemotherapy-induced diarrhea (CID) is a common side effect of cancer treatment and can cause significant morbidity and mortality. The experimental procedure included an oral treatment with S. pinnata bark extract prior (100 mg/Kg/day) or after (100 and 200 mg/ kg body wt.) the induction of a rat mucositis model by injecting a single dose of etoposide (i.p) and treated with S. pinnata bark extract (100 and 200 mg/ kg body wt.) for next 72 hrs. Treatment efficacy was determined by changes in the intestinal morphology and biochemical parameters such as intestinal TNF-α, Interleukin-6 (IL-6) and sodium potassium ATPase after 72 hr, with and without intervention. There was a significant increase in the IL-6 and TNF-α levels and a significant decrease in sodium potassium ATPase activities in intestinal tissue after etoposide injection. However, in the post treatment groups (in both 100 and 200 mg), IL-6 and TNF-α levels reverted back to that of normal. In study group, the animals exposed to Pre and post treatment with S. pinnata extract (100 mg/kg body wt), histological studies showed that S. pinnata bark extract intervention was able to restore the normal morphology and intestinal sodium potassium ATPase activity. The results suggest that S. pinnata bark extract has potentials to prevent the toxic effects of etoposide which expedites to mucositis.

Item Type: Article
Uncontrolled Keywords: Etoposide; Mucositis; S.pinnata; TNF-α and IL-6Na+; K+- ATPase
Subjects: Medicine > KMC Mangalore > Biochemistry
Depositing User: KMCMLR User
Date Deposited: 18 May 2015 06:24
Last Modified: 18 May 2015 06:24
URI: http://eprints.manipal.edu/id/eprint/142664

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