Transport of indomethacin from genipin cross-linked chitosan-gelatin composite hydrogels

Goyal, Aditya Sandeep and Divya, . and Kamath, Rajeshwari R and Thakur, Goutam (2015) Transport of indomethacin from genipin cross-linked chitosan-gelatin composite hydrogels. In: Fourth International Symposium Frontiers in Polymer Science (FPS-2015, May 20-22, 2015, Riva del Garda, Italy.

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An effort has been made to prepare hydrogel matrices using a combination of chitosan and gelatin, by cross-linking them with genipin, and examining the transport of Indomethacin. Since, chitosan and gelatin are biopolymers that have excellent biocompatibility; they have been used to develop the hydrogel matrices. Genipin is a naturally occurring and highly potent cross-linking agent that enhances the mechanical strength, and increases the stability due to formation of a semi-interpenetrating polymeric network (semi-IPN) within the hydrogel system. Indomethacin is the model drug used to study the transport of drugs from the hydrogel matrices. All procedures used were carried out in aqueous medium at neutral environment. In the study, hydrogel matrices have been inspected for their mechanical behavior. The swelling characteristics of composite hydrogels were investigated. The composite hydrogels displayed 200-300% increase in the swelling index. The compression test of the cross-linked hydrogels was determined and the compressive modulus of composite hydrogels was 0.0347 ± 0.003 MPa. Further, SEM micrographs showed interpenetrating networks of the composite hydrogels. Besides, the results also suggest that the surface of composite hydrogels is compact. Finally, the in vitro release profile of the model drug (Indomethacin) from the test hydrogels were evaluated using UV Vis spectrophotometry. The amount of indomethacin released at the beginning clearly suggest a burst release (~ 250%), and after approximately 14 h, the release attained steady state, confirming a sustained release effect. Overall, the results indicate that the composite gel could be a suitable polymeric carrier for the transport of indomethacin.

Item Type: Conference or Workshop Item (Poster)
Subjects: Engineering > MIT Manipal > Biomedical
Depositing User: MIT Library
Date Deposited: 30 May 2015 05:47
Last Modified: 30 May 2015 05:47

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