Zincovit Syrup Ameliorates Oxidative Stress Induced by Carbon Tetrachloride in Rats

Satyam, SM and Bairy, KL (2015) Zincovit Syrup Ameliorates Oxidative Stress Induced by Carbon Tetrachloride in Rats. International Journal of Basic & Clinical Pharmacology, 4 (3). pp. 449-452. ISSN 2279-0780

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Background: Zincovit (ZVT) syrup is a combined formulation of vitamins, minerals and lysine. The present study was aimed to investigate the in vivo antioxidant potential of ZVT syrup in carbon tetrachloride (CCl4) intoxicated Wistar rats. Methods: A total of 36 Wistar rats were divided into six groups of six rats each.Antioxidant potential of ZVT syrup at the dose of 15 mg/kg/day, 30 mg/kg/day and 60 mg/kg/day was evaluated in CCl4 intoxicated rats. The extent of CCl4 induced oxidative stress was studied by estimating malondialdehyde (MDA), glutathione-Stransferase (GST) and catalase (CAT).Results: Oral treatment with ZVT syrup, especially at the dose of 30 mg/kg/day and 60 mg/kg/day reversed CCl4 - induced alterations in MDA (p<0.05), GST (p<0.01) and CAT (p<0.01) compared to CCl4 intoxicated control (untreated) animals.Conclusion: The present findings revealed that ZVT syrup may be useful in oxidative stress associated tissue damage as a nutritional food supplement.

Item Type: Article
Uncontrolled Keywords: Zincovit syrup; Lysine; Zinc; Oxidative stress; Antioxidant; Carbon tetrachloride
Subjects: Medicine > MMMC Manipal > Pharmacology
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 02 Jun 2015 06:57
Last Modified: 02 Jun 2015 06:57
URI: http://eprints.manipal.edu/id/eprint/142880

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