Grape seed extract and zinc containing multivitaminmineral nutritional food supplement protects heart against myocardial Ischemia-reperfusion injury in wistar rats

Satyam, Shakta Mani and Bairy, KL and Vaishnav, Rajdip Lalit (2014) Grape seed extract and zinc containing multivitaminmineral nutritional food supplement protects heart against myocardial Ischemia-reperfusion injury in wistar rats. Austin Journal of Pharmacology and Therapeutics, 2 (4). pp. 1-6.

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Abstract

Zincovit tablets have been used as nutritional food supplement over a prolonged period of time. In previous studies, we had reported combined formulation of grape seed extract and Zincovit tablets for its strong in-vitro, in-vivo antioxidant, anti-hyperglycemic and anti-cataractogenic potential. Consequently, the aim of the present study was to investigate the cardio-protective effect of single combined formulation of grape seed extract and Zincovit tablets using a Langendorff model of ischemia-reperfusion in Wistar rats. Combined formulation of grape seed extract and Zincovit tablets significantly attenuated ischemia-reperfusion induced cardiac injury in terms of increased coronary flow rate, decreased creatine kinase activity in coronary effluent, decreased MDA, 4-HNE and increased protein thiol content in heart tissue homogenate. The present study revealed that the combined formulation of grape seed extract and Zincovit tablet is the potential functional nutritional food supplements that could offer a novel therapeutic opportunity against myocardial ischemia-reperfusion injury in Wistar rats.

Item Type: Article
Uncontrolled Keywords: Grape seed extract; zincovit tablets; cardiovascular disease; langendorff ischemia-reperfusion model; 4-hydroxynonenal; creatine kinase.
Subjects: Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 03 Jun 2015 06:25
Last Modified: 03 Jun 2015 06:25
URI: http://eprints.manipal.edu/id/eprint/142891

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