Burkholderia pseudomallei musculoskeletal infections (melioidosis) in India

Pandey, Vivek and Rao, Sripathi P and Rao, Sugandhi and Acharya, Kiran KV and Singh, Sarabjeet Chhabra (2010) Burkholderia pseudomallei musculoskeletal infections (melioidosis) in India. Indian Journal of Orthopaedics, 44 (2). pp. 216-220.

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Melioidosis, an infection due to gram negative Burkholderia pseudomallei, is an important cause of sepsis in east Asia especially Thailand and northern Australia. It usually causes abscesses in lung, liver, spleen, skeletal muscle and parotids especially in patients with diabetes, chronic renal failure and thalassemia. Musculoskeletal melioidosis is not common in India even though sporadic cases have been reported mostly involving soft tissues. During a two-year-period, we had five patients with musculoskeletal melioidosis. All patients presented with multifocal osteomyelitis, recurrent osteomyelitis or septic arthritis. One patient died early because of septicemia and multi-organ failure. All patients were diagnosed on the basis of positive pus culture. All patients were treated by surgical debridement followed by a combination of antibiotics; (ceftazidime, amoxy-clavulanic acid, co-trimoxazole and doxycycline) for six months except for one who died due to fulminant septicemia. All other patients recovered completely with no recurrences. With increasing awareness and better diagnostic facilities, probably musculoskeletal melioidosis will be increasingly diagnosed in future.

Item Type: Article
Uncontrolled Keywords: Burkholderia pseudomallei; melioidosis; musculoskeletal infection.
Subjects: Medicine > KMC Manipal > Microbiology
Medicine > KMC Manipal > Orthopaedics
Depositing User: KMC Manipal
Date Deposited: 19 Jun 2015 07:13
Last Modified: 19 Jun 2015 07:13
URI: http://eprints.manipal.edu/id/eprint/143069

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