Bioactive Caffeic Acid Esters from Glycyrrhiza Glabra

Setty, Manjunath M (2009) Bioactive Caffeic Acid Esters from Glycyrrhiza Glabra. Natural Product Research, 23 (18). pp. 1657-1663. ISSN 1029–2349

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Thin layer chromatography bioautography (using DPPH spray reagent) guided fractionation of Glycyrrhiza glabra led to the isolation of two caffeic acid derivative esters, viz. eicosanyl caffeate (1) and docosyl caffeate (2). The two compounds exhibited potent elastase inhibitory activity, with IC50 values of 0.99 mgmL�1 and 1.4 mgmL�1 for 1 and 2, respectively. The compounds also showed moderate antioxidant activity in DPPH and ABTS scavenging assays. The results indicate a possible role of caffeic acid derivatives, in addition to flavonoids in the anti-ulcer properties of G. glabra.

Item Type: Article
Uncontrolled Keywords: Antioxidant; Docosyl caffeate; DPPH; Eicosanyl caffeate; Elastase; Glycyrrhiza glabra
Subjects: Pharmacy > MCOPS Manipal > Pharmacognosy
Depositing User: KMC Manipal
Date Deposited: 20 Jun 2015 04:08
Last Modified: 20 Jun 2015 04:08

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