Zincovit drop reduces oxidative stress induced by carbon tetrachloride in rats

Satyam, Shakta Mani and Bairy, KL (2015) Zincovit drop reduces oxidative stress induced by carbon tetrachloride in rats. American Journal of Phytomedicine and Clinical Therapeutics, 3 (5). pp. 469-474. ISSN 2321 – 2748

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Abstract

Zincovit drop is a combined formulation of multivitamins-minerals, flax seed oil and lysine. This study has focused on the in vivo antioxidant potential of Zincovit drop against carbon tetrachloride induced oxidative stress in rats. Rats divided into six groups containing six rats in each group. Zincovit drop at the dose of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day was investigated in carbon tetrachloride intoxicated rats. Biochemical analysis of malondialdehyde, glutathione-S-transferase and catalase in liver tissue was performed. Oral treatment with Zincovit drop mostly at all the three doses 25, 50 and 100 mg/kg/day for 7 days reversed CCl4- induced alterations in malondialdehyde (p<0.01), glutathione-S- (p<0.001) and catalase (p<0.05) compared to carbon tetrachloride intoxicated control (untreated) animals. The present study demonstrated that Zincovit drop may be of great importance in oxidative stress associated diseases as nutritional food supplement.

Item Type: Article
Uncontrolled Keywords: Zincovit drop; Flaxseed oil; Lysine; Zinc; Oxidative stress; Carbon tetrachloride.
Subjects: Medicine > MMMC Manipal > Pharmacology
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 20 Jun 2015 06:22
Last Modified: 20 Jun 2015 06:22
URI: http://eprints.manipal.edu/id/eprint/143096

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