Effect of Ethanolic Extract of Hemidesmus indicus Roots on Cisplatin Induced Nephrotoxicity in Rats

Kaur, Arvinder and Shirwaikar, Annie and Setty, Manjunath M (2011) Effect of Ethanolic Extract of Hemidesmus indicus Roots on Cisplatin Induced Nephrotoxicity in Rats. Journal of Pharmacy Research, 4 (8). pp. 2523-2525. ISSN 0974-6943

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Abstract

The ethanolic extract of the roots of Hemidesmus indicus was investigated for its nephroprotective activity in Cisplatin induced renal injury in rats. In the curative regimen, the ethanolic extract at dose levels of 250 and 500 mg/kg showed dose-dependent reduction in the elevated blood urea and serum creatinine. There was increase in the GSH and GST enzyme level after treating rats with ethanolic extract of Hemidesmus indicus. The ethanolic extract also showed inhibition of Cisplatin induced lipid peroxidation. The results suggest that the alcoholic extract of the roots of Hemidesmus indicus possesses significant nephroprotective activity.

Item Type: Article
Uncontrolled Keywords: Hemidesmus indicus; Nephrotoxicity; Nephroprotection; Cisplatin
Subjects: Pharmacy > MCOPS Manipal > Pharmacognosy
Depositing User: KMC Manipal
Date Deposited: 22 Jun 2015 04:38
Last Modified: 22 Jun 2015 04:38
URI: http://eprints.manipal.edu/id/eprint/143104

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