Hepatoprotective effect of zincovit drop against carbon tetrachloride induced liver damage in wistar rats

Satyam, SM and Bairy, KL and Rao, Srinivasa Sirasanagandla (2015) Hepatoprotective effect of zincovit drop against carbon tetrachloride induced liver damage in wistar rats. Journal of Pharma Research, 4 (5). pp. 197-200. ISSN 2319-5622

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Abstract

The present study was aimed to investigate hepatoprotective activity of Zincovit drop on the CCl4 induced hepatotoxicity in Wistar rats. Hepatotoxicity was induced by administering CCl4 (1 ml/kg body weight; 1:1 CCl4 and olive oil). Zincovit drop at three different doses (25, 50 and 100 mg/kg/day, orally) were administered to the respective group of Wistar rats. Reference drug silymarin (50 mg/kg/day, orally) was given to one group of rats. The treatment duration was seven days. Biochemical parameters like serum alanine transaminase, aspartate transaminase, alkaline phosphatase, total bilirubin and direct bilirubin were estimated to assess the liver function. Biochemical observations were also supplemented with histopathological examination of liver section. Oral treatment with Zincovit drop reversed CCl4-induced alterations in serum aspartate transaminase (p<0.01) compared to untreated hepatotoxic control animals. In comparison with carbon tetrachloride induced hepatotoxic control group serum total bilirubin level was significantly decreased among Zincovit drop treated animals at all the three doses 25 mg/kg (p<0.05), 50 mg/kg (p<0.01) and 100 mg/kg (p<0.001). There was also a significant decrease in aspartate transaminase (AST) level in hepatotoxic rats treated with 50 mg/kg of Zincovit drop when compared with silymarin 50 mg/kg/day) treated hepatotoxic rats (p<0.05). Profound fatty degeneration, fibrosis, and necrosis observed in the hepatic architecture of CCl4 intoxicated control animals were found to be normal in the animals treated with Zincovit drop. The present findings support a hepatoprotective potential of Zincovit drop against CCl4 induced liver injury in rats.

Item Type: Article
Uncontrolled Keywords: Zincovit drop; flaxseed oil; hepatotoxicity; liver function test; hepatotoxicity; carbon tetrachloride.
Subjects: Medicine > MMMC Manipal > Anatomy
Medicine > MMMC Manipal > Pharmacology
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Manipal
Date Deposited: 26 Jun 2015 09:39
Last Modified: 26 Jun 2015 09:39
URI: http://eprints.manipal.edu/id/eprint/143152

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