HLA antigen distribution in renal transplant patients & donors visiting tertiary care hospital of Karnataka State in South India

Adiga, Murali and Pai, Kirtana M and Adhikari, Snehunsu and Rajesh, T and Sivakumar, G (2015) HLA antigen distribution in renal transplant patients & donors visiting tertiary care hospital of Karnataka State in South India. International Journal of Physiology, 3 (2). pp. 53-58. ISSN 2320-6039

[img] PDF
58 to 63.pdf - Published Version
Restricted to Registered users only

Download (161kB) | Request a copy

Abstract

Renal transplantation is the most successful treatment option for chronic renal failure patients. But success of this depends on HLA antigen matching between the renal recipient & donor. This study is the first report from Karnataka state of South India to find out distribution of HLA-A and B antigens in live renal transplant recipients and donors visiting a tertiary care hospital.In a retrospective study, HLA-A and B allele frequencies were studied in 345 renal transplant recipients & donors visiting our hospital, between 2005-2013. HLA tissue typing was done by polymerase chain reaction using sequence specific primers .Then Allele frequencies were obtained & analysed. A total of 32 HLA-A and 40 HLA-B alleles were identified in the live renal transplant recipients & donors. High frequency A alleles found in our patients & donors were- A*24(16%),A*33(13.6%),A*02(13.5%),A*11(11.4%),A* 01(9.6%). The most frequent alleles in the HLA-B locus were B*40(15%), B*07(13.4%), B*35(12.7%), B*51(8.8%), B*44(7.6%). Also we have found that females dominated among donors. The results showed significant heterogeneity in both HLA-A and B antigens. By knowing the frequency of HLA antigens in population,it is easy to find HLA matched organ transplant recipient & donors from different ethnic background, without a blood relationship.

Item Type: Article
Uncontrolled Keywords: Allele; renal transplantation; HLA.
Subjects: Medicine > MMMC Manipal > Anatomy
Medicine > KMC Manipal > Physiology
Depositing User: KMC Manipal
Date Deposited: 08 Jul 2015 05:42
Last Modified: 08 Jul 2015 05:42
URI: http://eprints.manipal.edu/id/eprint/143278

Actions (login required)

View Item View Item