Cyclooxygenase-2 - An Imperative Prognostic Biomarker in Oral Squamous Cell Carcinoma- An Immunohistochemical Study

Sen, Subhalakshmi and Guddattu, Vasudeva and Solomon, Monica Charlotte (2015) Cyclooxygenase-2 - An Imperative Prognostic Biomarker in Oral Squamous Cell Carcinoma- An Immunohistochemical Study. Pathology and Oncology Research.

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Abstract

Oral squamous cell carcinoma (OSCC) is the most common head and neck squamous cell carcinoma (HNSCC) with metastasis and tumor recurrence resulting in 90 % of cancer associated mortality. COX-2, an inflammatory biomarker, has been shown to playa significant role in tumorigenesis of OSCC. To study the expression ofCOX-2 in OSCC by immunohistochemistry and investigate its association with the clinicopathological parameters including patient survival. A cross sectional study was carried out in 75 histologically confinned cases ofOSCC. COX-2 expression was evaluated by indirect streptavidin biotin method. The expression was semi-quantitatively assessed using established criteria, The expression profile of COX-2 was correlated with the clinicopathological details like tumor size, regional lymphnode metastasis, distant metastasis, clinical stage, local recurrence of tumor, histological grade, and survival of patient. Chi square and Kaplan Meier statistical tests were applied for assessing this association. COX-2 expression was absent in normal oral mucosa. Over expression ofCOX-2 was seen in 58 out of75 specimens of OSCC. Overexpression of COX-2 was significantly associated with the Iymphnode involvement, histological grade, local recurrence of tumor and patient survival. COX-2 expression represents an important biomarker of prognostic significance that may be used to identify a subset of patients at high risk and to predict patient survival.

Item Type: Article
Uncontrolled Keywords: Carcinoma; Squamous cell; Cyclooxygenase 2 ; Immunohistochemistry.
Subjects: Dentistry > MCODS Manipal > Oral Pathology and Microbiology
Departments at MU > Statistics
Depositing User: KMC Manipal
Date Deposited: 20 Jul 2015 07:14
Last Modified: 20 Jul 2015 07:14
URI: http://eprints.manipal.edu/id/eprint/143364

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