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Current treatment for pulmonary hypertension

Kiran, HS and Vidyasagar, Sudha and Umakanth, Shashikiran (2004) Current treatment for pulmonary hypertension. Internet Journal of Pulmonary Medicine, 4 (2). pp. 14-15. ISSN 1531-2984

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Abstract

Pulmonary hypertension is a fatal disease. When left untreated, it progresses to death from right heart failure. Prostaglandins and their analogues are the mainstay of treatment. Intravenous Prostaglandins, Epoprostenol and Prostaglandins and their analogues are the mainstay of treatment. Intravenous Prostaglandins, Epoprostenol and calcium channel blockers are in use since many years. Several recent trials have established the efficacy of newer drugs. Trepostinil is a prostacyclin analogue which can be given as subcutaneous infusion. Iloprost is a prostaglandin analogue which can be given through intravenous as well as inhalational route. Beraprost can be used orally. Bosentan is a nonselective dual Endothelin receptor antagonist while Sitaxsentan is an oral selective Endothelin A receptor blocker. L Arginine , a precursor of Nitric Oxide can be used orally. Sildenafil, a phosphodiesterase inhibitor appears promising. Several options are now available for the treatment of pulmonary hypertension in addition to other adjunctive therapies. Present treatment options for pulmonary hypertension are discussed. However, further studies are required to evaluate the long-term efficacy of these drugs.

Item Type: Article
Uncontrolled Keywords: Beraprost; bosentan; calcium channel blockers; endothelin receptor antagonist ; epoprostenol; iloprost; l arginine; phosphodiesterase inhibitor; prostaglandins; pulmonary hypertension; sildenafil.
Subjects: Medicine > KMC Manipal > Medicine
Depositing User: KMC Manipal
Date Deposited: 28 Jul 2015 09:39
Last Modified: 28 Jul 2015 09:39
URI: http://eprints.manipal.edu/id/eprint/143586

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