Masquerading mammary hamartomas

Shivamurthy, Archana and Valiathan, Manna and Vasudevan, Geetha and Kudva, Ranjini and Rao, Anuradha CK and Pai, Kanthilatha and Monappa, Vidya and Jaiprakash, Padmapriya (2015) Masquerading mammary hamartomas. Journal of Evolution of Medical and Dental Sciences, 4 (44). pp. 7658-7663. ISSN 2278-4748

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Introduction: Hamartoma of the breast is a rare entity, frequently underdiagnosed by pathologists. It is a benign tumour-like nodule with overgrowth of mature cells that normally occur in the affected part. Patients present at an average of 45 yrs. with a unilateral, well defined, painless mass or enlargement; incidence being 0.1% to 0.7%. The aim of our study was to investigate clinical and histopathological features of breast hamartomas. Materials and Methods: Eighteen cases of breast hamartomas operated our hospital, between Jan. 2005 to Dec. 2012 were included in this study. The clinicopathological features and follow up data were analysed in all the cases. Results: All cases in our study were female patients with age group ranged between 23-40 yrs. All patients presented with unilateral breast masses. Clinically majority of patients were suspected to have fibroadenoma with only 2 cases suspected to be cystosarcoma phyllodes. Lumpectomy was performed in all the cases. Grossly all tumors were well circumscribed, grey white, lenticular masses with some showing cystic changes, myxoid areas and nodular areas. The maximum dimension of the tumors ranged from 4 to 16 cms. Microscopically, all hamartomas demonstrated good demarcation with fibrous tissue condensation and hyalinisation. Epitheliosis, apocrine metaplasia, pseudo angiomatous stromal hyperplasia, atrophy and cystically dilated ducts were among the major microscopic features observed. No recurrence or malignant components were noted in our case series. Conclusion : The diagnosis of hamartoma is difficult as no specific diagnostic histological features are present. The presence of fibrous tissue within the lobules, or fibrous tissue and fat in the stroma, with or without pseudoangiomatous changes, should alert the pathologist to the possibility of a hamartoma. The role of FNAC and needle core biopsy is limited. Coincidental malignancy can occur in hamartomas and hence the importance of its diagnosis.

Item Type: Article
Uncontrolled Keywords: Mammary hamartoma; Lenticular; Pseudoangiomatous change.
Subjects: Medicine > MMMC Manipal > Pathology
Medicine > KMC Manipal > Pathology
Depositing User: KMC Manipal
Date Deposited: 29 Jul 2015 04:34
Last Modified: 29 Jul 2015 04:34

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