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Triphala, an ayurvedic rasayana drug, protects mice against radiation- induced lethality by free-radical scavenging

Jagetia, Ganesh Chandra and Malagi, KJ and Baliga, Manjeshwar Shrinath and Venkatesh, Ponemone and Reddy, Rose Veruva (2004) Triphala, an ayurvedic rasayana drug, protects mice against radiation- induced lethality by free-radical scavenging. The Journal Of Alternative And Complementary Medicine, 10 (6). pp. 971-978.

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Abstract

The effects of 10 mg/kg of triphala extract (TE) was studied on radiation-induced sickness and mortality in mice exposed to 7-12 Gray (Gy) of -y-irradiation. Treatment of mice with triphala once daily for 5 consecutive days before irradiation delayed the onset of mortality and reduced the symptoms of radiation sickness when compared with the non-drug double distilled water treated irradiated controls (DDW). Triphala provided protection against both gastrointestinal and hemopoetic death. However, animals of both the TE + irradiation and DDW + irradiation groups did not survive up to 30 days post-irradiation beyond 11 Gy irradiation. The LDso/3o was found to be 8.6 Gy for the DDW + irradiation group and 9.9 Gy for TE + irradiation group. The administration of triphala resulted in an increase in the radiation tolerance by 1.4 Gy, and the dose reduction factor was found to be 1.15. To understand the mechanism of action of triphala, the free radical scavenging activity of the drug was evaluated. Triphala was found to scavenge ·OH, O2.- 2,2' -azinobis(3-ethylbenzthiazoline- 6-sulfonate) diammonium salt (ABTSr+ and NO· radicals in a dose dependent manner.

Item Type: Article
Subjects: Medicine > KMC Manipal > Ayurveda
Life Sciences > MLSC Manipal
Depositing User: KMC Manipal
Date Deposited: 05 Aug 2015 05:10
Last Modified: 05 Aug 2015 05:10
URI: http://eprints.manipal.edu/id/eprint/143750

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