Evaluation of antidepressant like activity in Amaranthus caudatus

Khan, Saleemulla (2015) Evaluation of antidepressant like activity in Amaranthus caudatus. Mahidol University Journal of Pharmaceutical Sciences, 42 (1). pp. 23-28.

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Abstract

Depression is a chronic illness that affects mental stability, personal and social relations. Herbal drugs possess least side effects compared to synthetic medicines. Amaranthus caudatus belongs to family Amaranthaceae. Antidepressant activity of methanolic extract of whole plant of Amaranthus caudatus (MEAC) was investigated by using forced swimming test (FST) and tail suspension test (TST) models. Animals are divided into five groups, group 1 receives normal saline, group 2 and 3 receives escitalopram (4 mg/kg) and imipramine (4 mg/kg) and group 4 and 5 receives MEAC (100 and 200 mg/kg) dose respectively. Preliminary phytochemical analysis showed the presence of phenolic compounds, steroids, alkaloids, flavonoids, saponins and amino acids in methanol extract of A. caudatus. It has been observed from our study that both the Amaranthus caudatus extract at higher concentration showed significant (p<0.01) reduction in immobility in tail suspension and forced swim model which comparable to escitalopram and imipramine. It is concluded that A. caudatus possess antidepressant activity may be due to the presence of polyphenolic compounds and flavonoids. However further study is needed to understand mechanism of action and to identify active component responsible for antidepressant like activity.

Item Type: Article
Uncontrolled Keywords: Amaranthus caudatus; Antidepressant activity; Tail suspension test; Forced swimming test
Subjects: Pharmacy > MCOPS Manipal > Pharmacognosy
Depositing User: KMC Manipal
Date Deposited: 06 Aug 2015 04:20
Last Modified: 06 Aug 2015 04:20
URI: http://eprints.manipal.edu/id/eprint/143766

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