Synthesis and Evaluation of Antitubercular Activity of Novel Diphenyl Ether Derivatives

Thomas, Cinu A and Kar, Sidhartha S and Bairy, Indira and Bhat, Varadaraj G and Shenoy, Vishnu Prasad and Shenoy, Gautham G (2015) Synthesis and Evaluation of Antitubercular Activity of Novel Diphenyl Ether Derivatives. Indo Global Journal of Pharmaceutical Sciences, 5 (1). pp. 19-25. ISSN 2249- 1023

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Abstract

Novel derivatives of diphenyl ether scaffold were synthesized and evaluated for the antitubercular activity. All the synthesized molecules were characterized by spectral analysis. Evaluation of antitubercular activity of the molecules by Microplate Alamar Blue Assay (MABA) showed less to moderate activity in comparison with Triclosan. All the molecules exhibited an acceptable safety profile in the MTT assay against vero and HepG2 cell lines. © 2014 iGlobal Research and Publishing Foundation. All rights reserved.

Item Type: Article
Uncontrolled Keywords: Diphenyl Ether; Antitubercular Activity; Triclosan; Safety Profile
Subjects: Medicine > KMC Manipal > Microbiology
Pharmacy > MCOPS Manipal > Pharmaceutical Chemistry
Depositing User: KMC Manipal
Date Deposited: 08 Aug 2015 09:26
Last Modified: 08 Aug 2015 09:26
URI: http://eprints.manipal.edu/id/eprint/143789

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