Low level laser therapy against radiation induced oral mucositis in elderly head and neck cancer patients-a randomized placebo controlled trial

Gautam, Ajay P and Fernandes, Donald J and Vidyasagar, Sudha and Maiya, Arun G and Guddattu, Vasudeva (2015) Low level laser therapy against radiation induced oral mucositis in elderly head and neck cancer patients-a randomized placebo controlled trial. Journal of Photochemistry and Photobiology B: Biology, 144. pp. 51-56.

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Abstract

Objectives: Radiotherapy (RT) is treatment of choice for Elderly Head and Neck Cancer (HNC) patients. Oral mucositis (OM) during RTaffects patient's routine oral activities and overall health. LowLevelLaser Therapy (LLLT)provided some promising results against cancer therapy induced OM in children and adults. Nostudy specifically evaluated effects of LLLTagainst RTinduced OMin elderly HNCpatients until date, hence we did this study, Material and methods: This double blinded study randomized 46 elderly HNCpatients scheduled for RT [Dosage = 66 Gray (2 Gy/fraction), 5 fractions/week, total 33 fractions for 6.5 weeks]. into laser (22) and placebo (24) groups. Laser group patients received LLLT[Helium-Neon, ,.\= 632.8 nm, power density = 0.024 W/cm2, dosage = 3.0J/point at six anatomical sites bilaterally I.e. 12 locations, total dose/session = 36 J, beam aperture diameter = 0.6 mm, beam spot size = 1 crrr', irradiated area diameter = 1 crrr', irradiation time/point = 125 s, 5 sessions/week, non-contact method-distance between probe and irradiated tissues <1 ern, whereas placebo group did not receive laser. OM grades (RTOG/ EORTCScale), oral pain, weight loss, need for morphine analgesics and tube feeding, and RTbreak were recorded by a blinded assessor. Descriptive statistics and repeated measures ANOVAwere used for analysis keeping p <0.05. Results: Significant reduction in the incidence and duration of severe OM (p = 0.016) and severe pain (p = 0.023) and weight loss (p = 0.004) was observed in laser than placebo group. No difference was found for enteral feeding use (p = 0.667) between two groups. Conclusions: LLLTdecreased the severity of OMand oral pain in elderly HNCpatients. Also, lesser weight loss, morphine analgesic use and radiation break happened in laser group.

Item Type: Article
Subjects: Allied Health > MCOAHS Manipal > Physiotherapy
Departments at MU > Statistics
Medicine > KMC Manipal > Radiotherapy and Oncology
Depositing User: KMC Manipal
Date Deposited: 10 Aug 2015 04:38
Last Modified: 10 Aug 2015 04:38
URI: http://eprints.manipal.edu/id/eprint/143802

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