MU Digital Repository
Logo

Acute phase proteins in newly diagnosed diabetics

*, Shaikh Shamim M and D’Souza, Vivian and Manjrekar, Poornima (2008) Acute phase proteins in newly diagnosed diabetics. Biomedical Research, 19 (1). pp. 49-53.

[img] Image (JPEG)
Article.jpg - Published Version
Restricted to Registered users only

Download (424kB) | Request a copy
[img] Image (JPEG)
Article 001.jpg - Published Version
Restricted to Registered users only

Download (422kB) | Request a copy
[img] Image (JPEG)
Article 002.jpg - Published Version
Restricted to Registered users only

Download (297kB) | Request a copy
[img] Image (JPEG)
Article 003.jpg - Published Version
Restricted to Registered users only

Download (531kB) | Request a copy
[img] Image (JPEG)
Article 004.jpg - Published Version
Restricted to Registered users only

Download (437kB) | Request a copy
[img] Image (JPEG)
Article 005.jpg - Published Version
Restricted to Registered users only

Download (306kB) | Request a copy

Abstract

A cytokine-mediated acute phase response is observed to be closely involved in the pathogenesis of type 2 diabetes. The role of inflammation in type 1 diabetes is contradictory. Since Indians are at high risk of developing diabetes, we tested this hypothesis by estimating circulating acute phase proteins in both type 1 (T-1) and type 2 (T-2) diabetic patients. The acute phase proteins, α1- antitrypsin, α1- acid glycoprotein, ceruloplasmin and fibrinogen were estimated in the plasma in newly diagnosed 12 T-1 and 25 T-2 cases. Thirty normal controls to match the age and sex of the test groups were also studied. The levels of these proteins were correlated with their BMI and random plasma glucose values. In comparison with the controls, T-1 cases showed significantly higher levels of the acute phase proteins (except α1- acid glycoprotein). The values of all the four proteins studied were significantly elevated in the T-2 patients (p<.00001). Except for ceruloplasmin levels, T-2 cases had significantly higher values when compared to the T-1 cases (p<.00001). Interestingly, no correlation was found with BMI or the degree of hyperglycemia in either of the types. A low grade inflammatory process is definitely implicated in the pathogenesis of both type 1 and type 2 diabetes. This line of pathological basis should be further explored for diagnosis, management and follow up.

Item Type: Article
Uncontrolled Keywords: Acute phase proteins, Ceruloplasmin, Fibrinogen, Newly diagnosed, Type 1 diabetes, Type 2 Diabetes
Subjects: Medicine > KMC Mangalore > Biochemistry
Depositing User: KMCMLR User
Date Deposited: 12 Aug 2015 06:46
Last Modified: 12 Aug 2015 06:46
URI: http://eprints.manipal.edu/id/eprint/143823

Actions (login required)

View Item View Item