Epidemiology and prevention of Type 2 Diabetes mellitus in children

*, Savindika Nawarathna and Jain, Animesh (2015) Epidemiology and prevention of Type 2 Diabetes mellitus in children. Journal of International Medicine and Dentistry, 2 (2). pp. 118-136. ISSN 2350-045X

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Abstract

Type 2 diabetes mellitus was considered rare amongst children, but recently the incidence has increased worldwide with almost half of the newly diagnosed cases being children and adolescents. Type 2 diabetes mellitus (T2DM) is primarily characterized by insulin resistance detected at the level of skeletal muscle, liver, and adipose tissues with a failure of β-cell compensation and a relative insulin deficiency. A variety of risk factors like race, obesity, insulin resistance, family history, psychococial factors, birth weight, exposure to maternal DM and breastfeeding can influence the development of T2DM. Type 2 DM screening in the paediatric population should be clinically focused and take into account not only those risk factors identified in the American Diabetes Association guidelines, but also the clinical context, pubertal status, and the results of simple screening measures such as fasting glucose and triglycerides. More outcome-based research is required before general screening, to identify children and adolescents with pre-diabetes or insulin resistance can be recommended.

Item Type: Article
Uncontrolled Keywords: Type 2 diabetes mellitus, insulin, children
Subjects: Medicine > KMC Mangalore > Community Medicine
Depositing User: KMCMLR User
Date Deposited: 21 Sep 2015 16:41
Last Modified: 21 Sep 2015 16:41
URI: http://eprints.manipal.edu/id/eprint/143969

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