In vitro biocompatibility and release of curcumin from curcumin microcomplex-loaded chitosan scaffold

Amirthalingam, Muthukumar and Kasinathan, Narayanan and Mutalik, Srinivas and Udupa, N (2015) In vitro biocompatibility and release of curcumin from curcumin microcomplex-loaded chitosan scaffold. Journal of Microencapsulation, 32 (4). pp. 364-371. ISSN 0265-2048

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Abstract

Context: Scaffold if suitably modified could be used as a drug delivery system. Objective: To develop chitosan scaffold as a delivery system for delivering curcumin in wound-healing application. Materials and methods: Chitosan–curcumin microcomplex particles were prepared, and the effect of drug–polymer ratio (DPR) and homogenisation speed (HS) was studied using a two-level full-factorial design. Chitosan scaffold was prepared and incorporated with curcumin microcomplexes to obtain a chitosan scaffold-containing chitosan–curcumin microcomplex (CS-CCM). Antimicrobial property of the CS-CCM against Escherichia coli was studied. The cytotoxicity of CS-CCM was studied by assessing the cell viability by MTT assay. Results and discussion: DPR had a significant effect (p�0.05) on the drug content. CS-CCM was able to inhibit the growth of E. coli considerably. The MTT results showed that CS-CCM is non-cytotoxic and supports cell proliferation. Conclusion: CS-CCM due to its biocompatibility and antimicrobial property could be further evaluated for potential application in wound healing.

Item Type: Article
Uncontrolled Keywords: Antimicrobial, biocompatibility, chitosan, factorial design, scaffold, wound healing.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutical Biotechnology
Pharmacy > MCOPS Manipal > Pharmaceutics
Pharmacy > MCOPS Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 22 Sep 2015 15:01
Last Modified: 22 Sep 2015 15:01
URI: http://eprints.manipal.edu/id/eprint/144020

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