Assessment of anti-dermatophytic activity of zincoderm GM cream in experimental tinea pedis in wistar rats

Satyam, SM and Bairy, KL and Musharaf, S and Fernandes, D and Peralam Yegneswaran, Prakash (2015) Assessment of anti-dermatophytic activity of zincoderm GM cream in experimental tinea pedis in wistar rats. International Journal of Pharmaceutical, Chemical and Biological Sciences, 5 (3). pp. 683-687. ISSN 2249-9504

[img] PDF
223.Assessment of antidermatophytic activity of zincoderm GM.pdf - Published Version
Restricted to Registered users only

Download (620kB) | Request a copy

Abstract

Zincoderm GM cream is a fixed dose combination of clobetasol, gentamicin, miconazole and zinc. Studies have been done for efficacy of each component like clobetasol, gentamicin and miconazole but as fixed dose combination including Zinc has not been reported yet. Hence a study was planned to assess the efficacy of Zincoderm GM cream in experimental Tinea pedis in animal models. In the experiment a total of 24 Wistar rats (male, pathogen free, 6-8 weeks old) were used. The rats were divided into 4 groups of 6 rats each. 25-30 mg of test drugs (Zincoderm GM cream with or without Zinc) was applied on infected paws from 10th day of post-infection. Fungal infection was assessed by clinical response scoring system and fungal culture examination. Clinical response (p<0.003) as well as fungal scores (p<0.001) was significantly lower in Tinea pedis induced rats treated with Zincoderm GM creamwith Zinc when compared to Tinea pedis induced control (untreated) rats. There was no significant difference in clinical response scores (P<0.0264) between Zincoderm GM with zinc and Zincoderm GM without zinc treatment groups. However, there was significantly lower fungal score(P<0.019) in Tinea pedis induced rats treated with Zincoderm GM cream with Zinc in comparison with Tinea pedis induced rats treated with Zincoderm GM cream without Zinc.

Item Type: Article
Uncontrolled Keywords: Tinea pedis; trichophyton rubrum; zincoderm GM; zinc.
Subjects: Medicine > MMMC Manipal > Pharmacology
Medicine > KMC Manipal > Microbiology
Medicine > KMC Manipal > Pharmacology
Depositing User: KMC Library
Date Deposited: 23 Sep 2015 15:23
Last Modified: 17 Dec 2015 09:07
URI: http://eprints.manipal.edu/id/eprint/144062

Actions (login required)

View Item View Item