Role of oral midazolam as a procedural sedative in children aged 6 months to 12 years

Kumar, Sandeep (2014) Role of oral midazolam as a procedural sedative in children aged 6 months to 12 years. International Journal of Pharma and Bio Sciences, 5 (4). pp. 488-495. ISSN 0975-6299

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Abstract

Pediatric procedural sedation is a safe, effective and humane way to facilitate appropriate medical care. We conducted a prospective, open-label randomized controlled trial in 272 children in the age group of 6 months to 12 years who need to undergo a procedure requiring pain or anxiety management. The objective was to evaluate the efficacy and safety profile of oral midazolam in comparison with intravenous midazolam. Out of 272 children, 42.5% children underwent invasive procedures and the rest non-invasive. For non-invasive procedures, 79% subjects in the oral group were adequately sedated, compared to 63% in the intravenous group. For invasive procedures, 71% subjects were adequately sedated with oral midazolam and 78% in intravenous group. 85% procedures were successfully completed in oral group compared to 79% in intravenous. Occurrence of adverse effects like desaturation, apnea and paradoxical hyper agitation was less with oral midazolam compared to intravenous.

Item Type: Article
Uncontrolled Keywords: Procedural sedation; analgesia; midazolam; children.
Subjects: Medicine > KMC Manipal > Paediatrics
Depositing User: KMC Library
Date Deposited: 24 Sep 2015 16:32
Last Modified: 24 Sep 2015 16:32
URI: http://eprints.manipal.edu/id/eprint/144114

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