Smart polymers in nasal drug delivery

Chonkar, Ankita and Nayak, Usha and Udupa, N (2015) Smart polymers in nasal drug delivery. Indian Journal of Pharmaceutical Sciences, 77 (4). pp. 367-375. ISSN 0250 - 474X

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Abstract

Nasal drug delivery has now been recognized as a promising route for drug delivery due to its capability of transporting a drug to systemic circulation and central nervous system. Though nasal mucosa offers improved bioavailability and quick onset of action of the drug, main disadvantage associated with nasal drug delivery is mucocilliary clearance due to which drug particles get cleared from the nose before complete absorption through nasal mucosa. Therefore, mucoadhesive polymeric approach can be successfully used to enhance the retention of the drug on nasal mucosal surface. Here, some of the aspects of the stimuli responsive polymers have been discussed which possess liquid state at the room temperature and in response to nasal temperature, pH and ions present in mucous, can undergo in situ gelation in nasal cavity. In this review, several temperature responsive, pH responsive and ion responsive polymers used in nasal delivery, their gelling mechanisms have been discussed. Smart polymers not only able to enhance the retention of the drug in nasal cavity but also provide controlled release, ease of administration, enhanced permeation of the drug and protection of the drug from mucosal enzymes. Thus smart polymeric approach can be effectively used for nasal delivery of peptide drugs, central nervous system dugs and hormones.

Item Type: Article
Uncontrolled Keywords: Nasal drug delivery; smart polymers; temperature responsive; pH responsive; ion responsive.
Subjects: Pharmacy > MCOPS Manipal > Pharmaceutics
Pharmacy > MCOPS Manipal > Pharmacy Management
Depositing User: KMC Library
Date Deposited: 25 Sep 2015 14:50
Last Modified: 25 Sep 2015 14:50
URI: http://eprints.manipal.edu/id/eprint/144145

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